We should ask our resident chemical expert?
I missed this thread earlier and it looks from the time-stamps that several posts occurred overnight.
Fructose, which is a naturally occurring sugar, can be very quickly absorbed in the gut. (Along with glucose and galactose.) We evolved from animals that ate a lot of fruit, which means that we adapted in a way to quickly get our nutrients from fruit sugars and carbohydrates. The danger of fructose in large quantities is that it has an unusually efficient path into the body. Therefore, it is very easy to have "too much of a good thing." The danger of high fructose corn syrup is that our evolutionary adaptation makes us vulnerable to it, loosely analogous to having open borders that allow too many people to come into the USA at once, too many to efficiently handle.
That is EXACTLY the problem with HFCS - too much HFCS means too much fructose to
efficiently handle in a short time. We convert sugars into energy to power our muscles and other parts of the body, but that conversion is rate-limited based on our body's ability to create the enzymes needed to perform that conversion. The excess eventually, thanks to another enzyme, insulin, converts to a type of fat and gets stored in our livers. Once that happens, you head towards non-alcoholic steato-hepatitis (NASH), which can lead to liver scarring and other bodily ills related to the digestive system. When you drive the body to produce more insulin because you have too much sugar, that is also rate-limited and can lead to a condition known as "insulin resistance." The large-scale inability to process blood sugars has a well-known name - diabetes. It all derives back to a simple concept - "too much of a good thing."
One normally does not discuss one's ills, but in this case I admit to having NASH as a problem, primarly caused by eating too much. Some time ago I started on a slow diet (because crash diets upset body equilibrium, too) and have lost over 18% of my highest body weight, shooting for 20% as my next goal weight. I am intimately familiar with this condition and therefore feel qualified to discuss it in this context.
Other issues include that excessive fat deposits can clog the nutrient distribution systems of our bodies - circulatory and heart disease. Fat build-up in the blood vessels (fats in the form of cholesterol) is also known as atherosclerosis. Dangerous side effects can include increased inflammation of a subtle, long-term, wide-spread nature. Inflammation has been linked to formation of beta-amyloids in the brain (and elsewhere), which in turn can lead to Alzheimer's Disease. Other body parts can be affected as well, such as the gall bladder, kidneys, and eyes (the latter primarily due to circulatory issues such as ocular atherosclerosis, leading to macular degeneration.) Severe atherosclerosis can lead to circulatory failure in the extremities, leading to amputation of gangrenous tissue. My brother-in-law recently lost his big toe to this condition, and about 20 years ago, one of the Navy's computer center operators lost a leg due to complications from diabetes.
A common question is the differences between sugars. The "fast path" for absorbtion for fructose, glucose, and galactose is because they are in the family of mono-saccharides. Sugars are created from ringed compounds. Mono-saccharides are single-ringed; disaccharides are two-ringed. You can have oligosaccharides (oily sugars) and polysaccharides (mono-saccharides that chemically bond with each other to form longer chains of mono-saccharide rings). The body can handle the bigger saccharides slowly over time but it really handles mono-saccharides the best among all sugars.
The danger of alcohol is that it is a component of sugars. More specifically, ethanol (C2H6O or, in subgroups, CH3.CH2.OH or hydroxy-ethane) is a structural component of sugars. At least three ethanol sub-groups appear in fructose. I counted four such groups in glucose. In the little diagram you can see that sucrose is just a bond between one glucose and one fructose so that is seven ethanol subgroups. Alcohol gets converted to sugar in the liver but part of the problem is that alcohol requires extra water molecules to be enzymatically merged and converted to sugar. Thus, when you have a hangover, your REAL problem is that your brain is dehydrated from all the water needed to process the alcohol.